Medicinal Chemistry in Anticancer Drug Design ππ§¬
Medicinal chemistry plays a transformative role in anticancer drug design, bridging laboratory innovation with real-world clinical applications π§ͺπ. By understanding cancer biology at the molecular level—such as oncogenes, tumor suppressors, and signaling pathways—medicinal chemists design targeted molecules that selectively attack cancer cells while minimizing harm to healthy tissues π―. Structure–activity relationship (SAR) studies, molecular docking, and rational drug design strategies enable the optimization of potency, selectivity, and pharmacokinetic properties, ensuring better therapeutic outcomes and reduced side effects. Modern anticancer drug discovery increasingly focuses on targeted therapies and personalized medicine π§¬π¬. Small-molecule inhibitors, monoclonal antibodies, and kinase inhibitors are developed based on specific genetic mutations and biomarkers identified in patients. Medicinal chemists refine these compounds to improve bioavailability, metabolic stabili...