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Induced-Proximity Therapeutics for Targeted Protein and RNA Degradation: An Organic Chemistry Perspective 🧬⚗️

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Induced-proximity therapeutics are transforming modern drug discovery by enabling the  selective degradation of disease-causing proteins and RNA  instead of merely inhibiting them. πŸš€ This strategy uses small organic molecules to bring a target biomolecule close to cellular degradation machinery, triggering its removal. From an organic chemistry viewpoint, the careful design of bifunctional ligands, linkers, and reactive warheads is essential for controlling stability, selectivity, and biological performance. These concepts are best seen in emerging platforms like PROTACs and RIBOTACs. πŸ”¬✨ Organic chemistry plays a central role in optimizing these systems by tuning functional groups, stereochemistry, and molecular interactions . πŸ§ͺ By engineering precise proximity between enzymes and targets, chemists can achieve efficient and controllable degradation. This approach overcomes limitations of traditional inhibitors, especially for “undruggable” proteins. Smart linker design, pol...

♻️ CO₂ Conversion via Co-Polymer Catalysts

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 πŸŒ  Turning CO₂ into Value with Smart Catalysts The synthesis and design of Co-complex polymers with built-in Lewis acid–base sites open exciting doors in sustainable chemistry. These advanced materials combine cobalt coordination centers with functional polymer backbones, creating highly active surfaces for green transformations. By tailoring the structure at the molecular level, researchers can enhance stability, reactivity, and recyclability, making these catalysts ideal for environmentally friendly processes. ♻️⚗️ πŸ”¬ Structure that Drives Performance The unique structure of Co-complex polymers allows Lewis acidic cobalt centers and Lewis basic groups to work cooperatively. This synergy improves CO₂ activation and promotes efficient cycloaddition reactions, converting carbon dioxide into valuable cyclic carbonates. At the same time, the porous polymer framework offers easy diffusion of reactants, boosting catalytic efficiency in Knoevenagel condensation reactions used for...

πŸ†Award For Scientific Contribution In Chemistry

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  Award for Scientific Contribution in Chemistry   celebrates exceptional researchers whose work advances chemical science and benefits society. This prestigious honor recognizes innovation, dedication, and impact across diverse fields such as analytical, organic, inorganic, physical, and materials chemistry. Awardees exemplify excellence through groundbreaking discoveries, high-quality publications, and meaningful contributions to education and industry. πŸ§ͺ✨ πŸ”¬ Chemistry drives progress in medicine, energy, environment, and technology, and this award highlights scientists who turn ideas into real-world solutions. From developing sustainable materials to improving drug design and environmental protection, recipients demonstrate leadership and creativity in addressing global challenges. Their achievements inspire the next generation of chemists to pursue curiosity with purpose. 🌍⚗️ 🌟 The Award for Scientific Contribution in Chemistry is more than recognition—it is a celebrat...

⚙️ Ni/Al₂O₃ catalysts are widely used due to their high activity and affordability,

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πŸ”¬ Modeling the combined deactivation and reaction kinetics of an impregnated Ni/Al₂O₃ catalyst in CO₂ methanation provides deep insight into how catalytic performance evolves over time. CO₂ methanation, also known as the Sabatier reaction, converts carbon dioxide into valuable methane using hydrogen, supporting carbon recycling and sustainable energy systems. By integrating kinetic modeling with catalyst aging behavior, researchers can better predict real-world performance under industrial operating conditions. ⚙️ Ni/Al₂O₃ catalysts are widely used due to their high activity and affordability , but they suffer from deactivation caused by sintering, carbon deposition, and metal oxidation. Modeling both reaction rates and deactivation simultaneously allows scientists to describe how active sites decrease during operation. This combined approach improves the accuracy of simulations, helping optimize temperature, pressure, and feed composition for long-term stable methane production. 🌍 ...

πŸŒπŸ“Š Blue Chemistry & BLOOM for Practical Reactions

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 πŸŒŠπŸ”¬  Blue Chemistry: A Novel Framework for Smarter Reaction Design Blue Chemistry is emerging as a powerful extension of sustainable science, focusing not only on making reactions greener but also more   practical   and scalable. Unlike traditional approaches, Blue Chemistry integrates environmental responsibility with real-world feasibility, ensuring that reactions are safe, efficient, and economically viable. By emphasizing simplicity, reduced waste, and energy-efficient processes, this framework helps chemists design pathways that work both in the lab and in industry, supporting innovation without compromising ecological balance. 🌱⚗️ πŸ’»πŸ“Š BLOOM Software: Turning Data into Practical Decisions The BLOOM software acts as a digital backbone for Blue Chemistry, enabling researchers to evaluate reaction practicality before execution. It analyzes parameters such as solvent safety, reagent availability, energy consumption, cost, and environmental impact in a single p...

🌱 Waving the Green Flag: Incorporating Sustainable and Green Chemistry Practices into Research and Education

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Green chemistry is transforming the way scientists design experiments, materials, and processes to protect both people and the planet. 🌍 By minimizing hazardous substances, reducing waste, and improving energy efficiency, sustainable chemistry encourages innovation without compromising environmental safety. From using renewable feedstocks to safer solvents and eco-friendly catalysts, researchers are now “waving the green flag” 🚩 to ensure that scientific progress aligns with global sustainability goals. In research laboratories, green chemistry promotes smarter experimentation and responsible resource management. πŸ§ͺ♻️ Scientists are adopting low-toxicity reagents, recycling solvents, and designing reactions with higher atom economy to reduce environmental impact. These practices not only cut costs but also improve laboratory safety and efficiency. Integrating life-cycle thinking into research helps evaluate the full impact of chemical products, making sustainability a core part of s...

⚙️ How Strain Relaxation Moves Cr in Cold-Worked Fe–Cr

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πŸ”¬  Understanding Strain Release in Fe–Cr Alloys Cold-worked Fe–Cr alloys store a large amount of internal strain due to plastic deformation. When this strain is released through thermal treatment or recovery processes, it significantly influences the redistribution of chromium (Cr) atoms within the iron matrix. This atomic movement plays a key role in controlling corrosion resistance, mechanical stability, and phase behavior of the alloy. Studying strain release helps scientists understand how microstructural changes occur after cold working. ⚙️πŸ§ͺ   🧫 How Chromium Atoms Rearrange During strain relaxation, defects such as dislocations and vacancies become active diffusion paths for Cr atoms. As the lattice recovers, chromium migrates from high-energy regions to more stable positions, modifying local composition. This redistribution can enhance passivation behavior, affect precipitation, and change magnetic and mechanical properties. Understanding this process allows researc...