Smart pH Model for Choline–Peptide IL Mixtures
Fast pH Estimation in Protic Ionic Liquid Solutions: A Smart Approach Using Choline–Amino Acid Systems,

Why Choline-Based Protic ILs Need a Smarter pH Model,
Protic ILs formed from choline cations and amino acid/peptide anions show strong hydrogen bonding, variable proton transfer, and complex dissociation behavior. Because of this, pH cannot be estimated simply from concentration or standard acid base equations . The new approach uses a combination of structure property relationships, ion dissociation parameters, and empirical correlations to determine pH rapidly. This helps researchers predict acidity even when the IL composition becomes highly tunable or when peptides introduce multiple protonation sites ✨.
Applications and Benefits: Faster Research, Greener Chemistry,
A rapid pH estimation method means faster optimization of IL-based solvents, drug delivery systems, electrochemical media, and biomolecular stabilizers . This also reduces chemical waste and shortens experimental cycles supporting green chemistry goals and sustainable research practices . With accurate, quick pH predictions for choline–amino acid or choline peptide IL solutions, scientists can explore new formulations, design better processes, and unlock innovative uses of biocompatible ionic liquids .
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